The Endocannabinoid system
Is a physical system that operates through out the body. The ECS system is integral to the bodies physiological processes. The body produces its own natural endocannabinoids that interact with a number of receptors. The bodies own endocannabinoids are similar molecules to Phytocannabinoids that derive from plants.
Cannabinoid receptors are found through out the body. The traditional way of looking at the system is to treat receptors as locks and cannabinoids as keys. But as more research adds to our accumulated knowledge this looks an outdated model.
We advocate a theory of Quantum Cannabinoid’s this works on the quantum level and is to do with molecular vibrational frequency.
The body produces its own endogenous Cannabinoids :-
- Anandamide the mimetic phytocannabinoid is THC.
- 2-Arachidonoylglycerol (2-AG) the mimetic phytocannabinoid is CBD.
Phytocannabinoid’s are cannabinoids produced by plants that occur naturally in the growth cycle.
Found in the nervous system, connective tissues, gland and organs.
Found in the immune system and other Phriphery systems.
Anandamide is known as the Bliss molecule aptly named because the word is derived from the Sanskrit word “ananda” meaning bliss. It occurs naturally in the body and fits CB1 and CB2 receptors.
2-Arachidonoylglycerol is a full agonist of the CB1 receptor. 2AG is associated with pain relief, suppression of vomiting and stimulation of appetite and the inhibition of tumor growth.
Tetrahydrocannabinol The primary phytocannabinoid found in Cannabis that has many uses and is responsible for the “Blyss feeling” it is psychoactive and fits CB1 receptors
Cannabinol is a weak psychoactive agent that acts mainly on the CB2 receptors.
Cannabidiol is none psychoactive and has many uses to balance the ECS. It acts indirectly on the Endocannabinoid system as antagonist.
These are the main Cannabiniod’s. But the UK government recognises 92 cannabinoids and only 17 are illegal because of the psychoactive effect. The UK government may be legislating in the near future for a more evidence based approach to the regulation of Cannabis.
How it works
What appears to happen is that there is much more of a spectrum or scale of influence than a single point of entry.
There are currently well defined knowledge on CB1 and CB2 receptors.
CB1 receptors are found mainly in the brain area with few found in the lung, Kidney, liver, fat, heart, muscle and bone. CB1 receptors are are activated in the main by the naturally occurring cannabinoid anandamide and the Photocannabinoid derived from cannabis, THC (tetrahydrocannabinol). Anandamide is a cannabinoid produced in the brain that binds to CB1 receptors. In an understated way science likes the word ananda was used to describe the cannabinoid. Ananda in sanskrit means Joy, pleasure, Blyss.
CB2 receptors are found mainly in the bodies immune system and blood cells they are also present in the nervous system and to a lesser extent is the liver stomach, muscle and bone.
Endocannabinoids are a class of neurotransmitters that retrograde the chemical signalling in the body. It forms part of the closed loop system that provides internal feedback to other stimulating neurotransmitters.
Its a complex science and its now showing just how intricate the interactions of the constituent parts can be. Find out more
A really clear detailed explanation of the Endocannabinoid system.